Neuromyolitis Optica (NMO) Antibodies (Aquaporin-4)

Specimen

Serum

Special Instructions

Minimum sample volume: 3 ml

Test Usage

Aquaporin 4 is the major autoantigen in neuromyelitis optica (NMO or Devic’s disease). Antibodies to AQP4 are found in >80% of NMO patients & around 50% of patients with longitudinally extensive transverse myelitis. They are infrequent in patients with optic neuritis without spinal cord involvement. Reviewed in: Jarius and Wildemann Nat Rev Neurol. 2010. Patients with AQP4 antibodies are at risk of relapsing, and immunosuppressive treatment is currently recommended before waiting for further events. Further guidance can be found at www.nmouk.nhs.uk

Turnaround time

Monthly

Availability

Referred Test

Assayed By

This investigation is performed at the Immunology Department, Churchill Hospital, Headington, Oxford, OX3 7LJ.