Serum
None
Age and sex appropriate reference ranges and units are reported with all clinical results. Reference ranges and units can also be found on the ‘Procedure Catalogue’ in EPIC.
17-OHP is an endogenous progestogen, stimulated by pituitary adrenocorticotrophic hormone (ACTH), as part of the hypothalamic–pituitary–adrenal axis.
17-OHP is primarily produced within the zona fasciculata of the adrenal cortex. It can also be produced by the corpus luteum, gonads, and placenta. 17-OHP is an intermediate in the production of cortisol in the zona fasciculata, and an intermediate in the production of adrenal androgens in the zona reticularis.
Concomitant corticosteroid treatment and pituitary dysfunction can suppress 17-OHP.
The measurement of 17-OHP is most commonly used for the investigation of CAH, as its accumulation is associated with deficiencies of several enzymes involved in steroid biosynthesis – the most common of these being 21-hydroxylase (CYP21A2) deficiency.
17-OHP measurement can aid in the investigation of patients with disorders of sexual differentiation, ambiguous genitalia, clitoromegaly, salt-wasting dehydration, symptoms of androgen excess, and premature adrenarche or precocious puberty.
17-OHP measurements, along with measurements of renin, can also be used for the monitoring of hydrocortisone replacement in these patients. A normal basal 17-OHP concentration does not exclude non-classical CAH.
https://labtestsonline.org.uk/
This test is referred to an external laboratory for analysis.
2 weeks.
Can be added onto an existing request up to 4 days following sample receipt.
Please refer to the UKAS website for test accreditation status.
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Specimen Labelling Procedure
8210
