Blood Sciences
Welcome to the home page of the Blood Sciences department at the Royal Devon & Exeter NHS Foundation Trust, UK.
The Exeter Blood Sciences Laboratory is a modern, high quality service generating >25,000 results everyday for both NHS and research patients. Along with our partner disciplines, we share the vision that a clinical diagnostic facility is underpinned by research, modern laboratory processes, and clinical expertise for differential diagnosis, result interpretation and treatment advice.
The combined laboratories provide a full range of Clinical Biochemistry, Haematology, Immunology and Blood Transfusion within the custom designed laboratories at the Royal Devon and Exeter NHS Foundation Trusts.
Information about sample requirements and reference ranges for specific test can be found on the test catalogue. General information regarding opening times and making requests can be found here.
Blood Sciences is a vibrant training laboratory with over 45 biomedical scientists and 9 clinical scientists receiving their training here over the last 15 years.
Tests that are accredited to ISO15189:2012 are detailed in our scope which can be found on the UKAS website: https://www.ukas.com/wp-content/uploads/schedule_uploads/00007/8210-Medical-Multiple.pdf
Clinical Biochemistry
General chemistry services are provided by the Department of Blood Sciences and a 24 hour, 7 day acute service available.
The Blood Sciences laboratory provides a comprehensive diagnostic service which includes general screening for renal, liver, bone, cardiac and other disease groups through the use of highly automated analytical platforms. In addition we provide an extensive disease monitoring service for monoclonal antibodies, anaemia, endocrine, lipid and other metabolic disorders.
The laboratory also provides specialist assay services to support research and clinical trials carried out in the Peninsula Medical School and the University of Exeter. We welcome referral work from other laboratories to support:
- First trimester Down’s screening
- Specialist diabetes services including: C-Peptide, Insulin, Proinsulin, Glucagon, GAD, IA2 and ZnT8
- Biologic drug and anti-drug antibody testing including Infliximab, adalimumab and vedolizumab
For any enquiries regarding clinical advice, please contact the Duty Biochemist who is available 24 hours a day: routine hours 09.00 – 17.30 Monday to Friday Tel: 01392 402935 OR by bleep through the switch board out of hours. Non-urgent enquiries can be e-mailed to: rduh.biochem@nhs.net
GPs can also use the e-Referral service (e-RS) for any non-urgent clinical advice and guidance.
Haematology
Haematology provides a comprehensive screening and diagnostic service using a range of state-of-the art technologies and manual laboratory procedures. The laboratory provides Full Blood Count and coagulation investigations, blood cell morphology, malaria and glandular fever screens and haemoglobinopathy assessment.
The clinical consultant leads are involved in day-to-day diagnosis, being responsible not only for clinical advice but also consultative support for complex blood cell morphology, and provide bone marrow aspirate and trephine assessment.
Blood Transfusion
The MHRA accredited laboratory provides the full range of immuno-haematological services, including antenatal screening for the prevention of haemolytic disease of the newborn and supports the trust programme for routine antenatal anti-D prophylaxis. The blood bank provides both standard and highly specialised blood and blood components to meet the diverse requirements of patients.
Haematology and Blood Transfusion laboratory service is provided on a 24 hour a day, 365 days a year basis.
Click here to visit the main Blood Transfusion page.
Immunology
The immunology laboratory provides allergy testing, protein electrophoresis, and a wide range of autoimmune tests.
Details of immunology tests for autoimmune disease can be found in our test catalogue.
Departmental Publications (Since January 2017)
- Young KG, McDonald TJ, Shields BM. Glycated haemoglobin measurements from UK Biobank are different to those in linked primary care records: implications for combining biochemistry data from research studies and routine clinical care. Int J Epidemiol. 2022 Jan 13;. doi: 10.1093/ije/dyab265. [Epub ahead of print] PubMed PMID: 35026015.
- Jones AG, McDonald TJ, Shields BM, Hagopian W, Hattersley AT. Latent Autoimmune Diabetes of Adults (LADA) Is Likely to Represent a Mixed Population of Autoimmune (Type 1) and Nonautoimmune (Type 2) Diabetes. Diabetes Care . 2021 Jun;44(6):1243-1251. doi: 10.2337/dc20-2834. Epub 2021 May 20.
- Katte JC, Lemdjo G, Dehayem MY, Jones AG, McDonald TJ, Sobngwi E, Mbanya JC. Mortality amongst children and adolescents with type 1 diabetes in sub-Saharan Africa: The case study of the Changing Diabetes in Children program in Cameroon. Pediatr Diabetes. 2022 Feb;23(1):33-37. doi: 10.1111/pedi.13294. Epub 2021 Nov 29. PubMed PMID: 34820965.
- Meek CL, Oram RA, McDonald TJ, Feig DS, Hattersley AT, Murphy HR; CONCEPTT Collaborative Group. Reappearance of C-Peptide During the Third Trimester of Pregnancy in Type 1 Diabetes: Pancreatic Regeneration or Fetal Hyperinsulinism? Diabetes Care. 2021 Aug;44(8):1826-1834. doi: 10.2337/dc21-0028. Epub 2021 Jun 26. PMID: 34175829.
- Wesolowska-Andersen A, Brorsson CA, Bizzotto R, Mari A, Tura A, Koivula R, Mahajan A, Vinuela A, Tajes JF, Sharma S, Haid M, Prehn C, Artati A, Hong MG, Musholt PB, Kurbasic A, De Masi F, Tsirigos K, Pedersen HK, Gudmundsdottir V, Thomas CE, Banasik K, Jennison C, Jones A, Kennedy G, Bell J, Thomas L, Frost G, Thomsen H, Allin K, Hansen TH, Vestergaard H, Hansen T, Rutters F, Elders P, t’Hart L, Bonnefond A, Canouil M, Brage S, Kokkola T, Heggie A, McEvoy D, Hattersley A, McDonald T, Teare H, Ridderstrale M, Walker M, Forgie I, Giordano GN, Froguel P, Pavo I, Ruetten H, Pedersen O, Dermitzakis E, Franks PW, Schwenk JM, Adamski J, Pearson E, McCarthy MI, Brunak S. Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study. Cell Rep Med. 2022 Jan 18;3(1):100477. doi: 10.1016/j.xcrm.2021.100477. eCollection 2022 Jan 18. PubMed PMID: 35106505; PubMed Central PMCID: PMC8784706.
- Carr ALJ, Oram RA, Marren SM, McDonald TJ, Narendran P, Andrews RC. Measurement of Peak C-Peptide at Diagnosis Informs Glycemic Control but not Hypoglycemia in Adults With Type 1 Diabetes. J Endocr Soc. 2021 Oct 1;5(10):bvab127. doi: 10.1210/jendso/bvab127. eCollection 2021 Oct 1. PubMed PMID: 34377883; PubMed Central PMCID: PMC8344843.
- *Grace SL, Cooper A, Jones AG, McDonald TJ. Zinc transporter 8 autoantibody testing requires age-related cut-offs. BMJ Open Diabetes Res Care. 2021 Aug;9(1). doi: 10.1136/bmjdrc-2021-002296. PubMed PMID: 34348918; PubMed Central PMCID: PMC8340275.
- Kennedy NA, Lin S, Goodhand JR, Chanchlani N, Hamilton B, Bewshea C, Nice R, Chee D, Cummings JF, Fraser A, Irving PM, Kamperidis N, Kok KB, Lamb CA, Macdonald J, Mehta S, Pollok RC, Raine T, Smith PJ, Verma AM, Jochum S, McDonald TJ, Sebastian S, Lees CW, Powell N, Ahmad T; Contributors to the CLARITY IBD study. Infliximab is associated with attenuated immunogenicity to BNT162b2 and ChAdOx1 nCoV-19 SARS-CoV-2 vaccines in patients with IBD. Gut. 2021 Oct;70(10):1884-1893. doi: 10.1136/gutjnl-2021-324789. Epub 2021 Apr 26.PMID: 33903149
- Chanchlani N, Lin S, Chee D, Hamilton B, Nice R, Zehra A, Bewshea C, Cipriano B, Derikx LAAP, Dunlop A, Greathead L, Griffiths RL, Ibraheim H, Kelleher P, Kok KB, Lees CW, MacDonald J, Sebastian S, Smith PJ, McDonald TJ, Irving PM, Powell N, Kennedy NA, Goodhand JR, Ahmad T. Adalimumab and infliximab impair SARS-CoV-2 antibody responses: results from a therapeutic drug monitoring study in 11422 biologic-treated patients. J Crohns Colitis. 2021 Sep 2;. doi: 10.1093/ecco-jcc/jjab153. [Epub ahead of print] PubMed PMID: 34473254; PubMed Central PMCID: PMC8499950.
- Tikhonova IA, Yang H, Bello S, Salmon A, Robinson S, Hemami MR, Dodman S, Kharechko A, Haigh RC, Jani M, McDonald TJ, Hoyle M.
- Kennedy NA, Goodhand JR, Bewshea C, Nice R, Chee D, Lin S, Chanchlani N, Butterworth J, Cooney R, Croft NM, Hart AL, Irving PM, Kok KB, Lamb CA, Limdi JK, Macdonald J, McGovern DP, Mehta SJ, Murray CD, Patel KV, Pollok RC, Raine T, Russell RK, Selinger CP, Smith PJ, Bowden J, McDonald TJ, Lees CW, Sebastian S, Powell N, Ahmad T; Contributors to the CLARITY IBD study. Anti-SARS-CoV-2 antibody responses are attenuated in patients with IBD treated with infliximab. Gut. 2021 Mar 22:gutjnl-2021-324388. doi: 10.1136/gutjnl-2021-324388. Online ahead of print. PMID: 33753421.
- Tikhonova IA, Yang H, Bello S, Salmon A, Robinson S, Hemami MR, Dodman S, Kharechko A, Haigh RC, Jani M, McDonald TJ, Hoyle M.. Enzyme-linked immunosorbent assays for monitoring TNF-alpha inhibitors and antibody levels in people with rheumatoid arthritis: a systematic review and economic evaluation. Health Technology Assessment Health Technol Assess. 2021 Feb;25(8):1-248. doi: 10.3310/hta25080. PMID: 33555998
- Bizzotto R, Jennison C, Jones AG, Kurbasic A, Tura A, Kennedy G, Bell JD, Thomas EL, Frost G, Eriksen R, Koivula RW, Brage S, Kaye J, Hattersley AT, Heggie A, McEvoy D, ‘t Hart LM, Beulens JW, Elders P, Musholt PB, Ridderstråle M, Hansen TH, Allin KH, Hansen T, Vestergaard H, Lundgaard AT, Thomsen HS, De Masi F, Tsirigos KD, Brunak S, Viñuela A, Mahajan A, McDonald TJ, Kokkola T, Forgie IM, Giordano GN, Pavo I, Ruetten H, Dermitzakis E, McCarthy MI, Pedersen O, Schwenk JM, Adamski J, Franks PW, Walker M, Pearson ER, Mari A. Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study. Diabetes Care. 2021 Feb;44(2):511-518. doi: 10.2337/dc20-1567. Epub 2020 Dec 15. PubMed PMID: 33323478.
- Jeyam A, Colhoun H, McGurnaghan S, Blackbourn L, McDonald TJ, Palmer CNA, McKnight JA, Strachan MWJ, Patrick AW, Chalmers J, Lindsay RS, Petrie JR, Thekkepat S, Collier A, MacRury S, McKeigue PM. Clinical Impact of Residual C-Peptide Secretion in Type 1 Diabetes on Glycemia and Microvascular Complications. Diabetes Care. 2021 Feb;44(2):390-398. doi: 10.2337/dc20-0567. Epub 2020 Dec 10. PubMed PMID: 33303639.
- Zhao J-F, Rodger CE, Allen GFG, Weidlich S, Ganley IG. HIF1a-dependent mitophagy facilitates cardiomyoblast differentiation. Cell Stress. 2020; 4(5): 99 -113.
- Bailey SER, Abel GA, Atkins A, Byford R, Davies SJ, Mays J, McDonald TJ, Miller J, Neck C, Renninson J, Thomas P, Walter FM, Warren S, Hamilton W. Diagnostic performance of a faecal immunochemical test for patients with low-risk symptoms of colorectal cancer in primary care: an evaluation in the South West of England. Br J Cancer. 2021 Jan 19;. doi: 10.1038/s41416-020-01221-9. [Epub ahead of print] PubMed PMID: 33462361.
- Nice R, Chanchlani N, Green H, Bewshea C, Ahmad T, Goodhand JR, McDonald TJ, Perry MH, Kennedy NA. Validating the positivity thresholds of drug-tolerant anti-infliximab and anti-adalimumab antibody assays. Aliment Pharmacol Ther. 2021 Jan;53(1):128-137. doi: 10.1111/apt.16135. Epub 2020 Nov 23. PubMed PMID: 33226651.
- Niwaha AJ, Rodgers LR, Greiner R, Balungi PA, Mwebaze R, McDonald TJ, Hattersley AT, Shields BM, Nyirenda MJ, Jones AG. HbA1c performs well in monitoring glucose control even in populations with high prevalence of medical conditions that may alter its reliability: the OPTIMAL observational multicenter study. BMJ Open Diabetes Res Care. 2021 Sep;9(1). doi: 10.1136/bmjdrc-2021-002350. PubMed PMID: 34535465; PubMed Central PMCID: PMC8451306.
- *Chee D, Nice R, Hamilton B, Jones E, Hawkins S, Redstone C, Cairnes V, Pohl K, Chanchlani N, Lin S, Kennedy NA, Ahmad T, Goodhand JR, McDonald TJ. Patient-led Remote IntraCapillary pharmacoKinetic Sampling (fingerPRICKS) for therapeutic drug monitoring in patients with inflammatory bowel disease. J Crohns Colitis. 2021 Jul 21;. doi: 10.1093/ecco-jcc/jjab128. PubMed PMID: 34289028.
- Rodgers LR, Hill AV, Dennis JM, Craig Z, May B, Hattersley AT, McDonald TJ, Andrews RC, Jones A, Shields BM. Choice of HbA1c threshold for identifying individuals at high risk of type 2 diabetes and implications for diabetes prevention programmes: a cohort study. BMC Med. 2021 Aug 20;19(1):184. doi: 10.1186/s12916-021-02054-w. PubMed PMID: 34412655; PubMed Central PMCID: PMC8377980.
- Johnson MB, Patel KA, De Franco E, Hagopian W, Killian M, McDonald TJ, Tree TIM, Domingo-Vila C, Hudson M, S, Flanagan SE, Hattersley AT, Oram RA. Type 1 diabetes can present before the age of 6 months and is characterised by autoimmunity and rapid loss of beta cells. Diabetologia. 2020 Dec;63(12):2605-2615. doi: 10.1007/s00125-020-05276-4. Epub 2020 Oct 8. PubMed PMID: 33029656; PubMed Central PMCID: PMC7641942.
- Gudmundsdottir V, Pedersen HK, Mazzoni G, Allin KH, Artati A, Beulens JW, Banasik K, Brorsson C, Cederberg H, Chabanova E, De Masi F, Elders PJ, Forgie I, Giordano GN, Grallert H, Gupta R, Haid M, Hansen T, Hansen TH, Hattersley AT, Heggie A, Hong MG, Jones AG, Koivula R, Kokkola T, Laakso M, Løngreen P, Mahajan A, Mari A, McDonald TJ, McEvoy D, Musholt PB, Pavo I, Prehn C, Ruetten H, Ridderstråle M, Rutters F, Sharma S, Slieker RC, Syed A, Tajes JF, Thomas CE, Thomsen HS, Vangipurapu J, Vestergaard H, Viñuela A, Wesolowska-Andersen A, Walker M, Adamski J, Schwenk JM, McCarthy MI, Pearson E, Dermitzakis E, Franks PW, Pedersen O, Brunak S. Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study. Genome Med. 2020 Dec 1;12(1):109. doi: 10.1186/s13073-020-00806-6. PubMed PMID: 33261667; PubMed Central PMCID: PMC7708171.
- Bar N, Korem T, Weissbrod O, Zeevi D, Rothschild D, Leviatan S, Kosower N, Lotan-Pompan M, Weinberger A, Le Roy CI, Menni C, Visconti A, Falchi M, Spector TD, Adamski J, Franks PW, Pedersen O, Segal E. A reference map of potential determinants for the human serum metabolome. Nature. 2020 Dec;588(7836):135-140. doi: 10.1038/s41586-020-2896-2. Epub 2020 Nov 11. PubMed PMID: 33177712.
- Obura M, Beulens JWJ, Slieker R, Koopman ADM, Hoekstra T, Nijpels G, Elders P, Koivula RW, Kurbasic A, Laakso M, Hansen TH, Ridderstråle M, Hansen T, Pavo I, Forgie I, Jablonka B, Ruetten H, Mari A, McCarthy MI, Walker M, Heggie A, McDonald TJ, Perry MH, De Masi F, Brunak S, Mahajan A, Giordano GN, Kokkola T, Dermitzakis E, Viñuela A, Pedersen O, Schwenk JM, Adamski J, Teare HJA, Pearson ER, Franks PW, ‘t Hart LM, Rutters F. Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study. PLoS One. 2020;15(11):e0242360. doi: 10.1371/journal.pone.0242360. eCollection 2020. PubMed PMID: 33253307; PubMed Central PMCID: PMC7703960.
- ** Shepherd M, Knight BA, Laskey K, McDonald TJ. Parental experiences of a diagnosis of neonatal diabetes and perceptions of newborn screening for glucose: a qualitative study. BMJ Open. 2020 Nov 4;10(11):e037312. doi: 10.1136/bmjopen-2020-037312. PubMed PMID: 33148726; PubMed Central PMCID: PMC7643500.
- Taylor GS, Smith K, Capper TE, Scragg JH, Bashir A, Flatt A, Stevenson EJ, McDonald TJ, Oram RA, Shaw JA, West DJ. Postexercise Glycemic Control in Type 1 Diabetes Is Associated With Residual β-Cell Function. Diabetes Care. 2020 Oct;43(10):2362-2370. doi: 10.2337/dc20-0300. Epub 2020 Aug 3. PubMed PMID: 32747405; PubMed Central PMCID: PMC7510016.
- Eriksen R, Perez IG, Posma JM, Haid M, Sharma S, Prehn C, Thomas LE, Koivula RW, Bizzotto R, Prehn C, Mari A, Giordano GN, Pavo I, Schwenk JM, De Masi F, Tsirigos KD, Brunak S, Viñuela A, Mahajan A, McDonald TJ, Kokkola T, Rutter F, Teare H, Hansen TH, Fernandez J, Jones A, Jennison C, Walker M, McCarthy MI, Pedersen O, Ruetten H, Forgie I, Bell JD, Pearson ER, Franks PW, Adamski J, Holmes E, Frost G. Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI DIRECT study. EBioMedicine. 2020 Aug;58:102932. doi: 10.1016/j.ebiom.2020.102932. Epub 2020 Aug 4. PubMed PMID: 32763829; PubMed Central PMCID: PMC7406914.
- JC Katte, V Poka-Mayap, A Niwaha, W Nakanga, A Jones, TJ McDonald et al. Post-meal Urinary C-peptide creatinine ratio is a moderate measure of insulin secretion in diabetes patients in Cameroon: results from a cross-sectional study. PAMJ-Clinical Medicine 3 (12) 2020
- Atabaki-Pasdar N, Ohlsson M, Viñuela A, Frau F, Pomares-Millan H, Haid M, Jones AG, Thomas EL, Koivula RW, Kurbasic A, Mutie PM, Fitipaldi H, Fernandez J, Dawed AY, Giordano GN, Forgie IM, McDonald TJ, Rutters F, Cederberg H, Chabanova E, Dale M, Masi F, Thomas CE, Allin KH, Hansen TH, Heggie A, Hong MG, Elders PJM, Kennedy G, Kokkola T, Pedersen HK, Mahajan A, McEvoy D, Pattou F, Raverdy V, Häussler RS, Sharma S, Thomsen HS, Vangipurapu J, Vestergaard H, ‘t Hart LM, Adamski J, Musholt PB, Brage S, Brunak S, Dermitzakis E, Frost G, Hansen T, Laakso M, Pedersen O, Ridderstråle M, Ruetten H, Hattersley AT, Walker M, Beulens JWJ, Mari A, Schwenk JM, Gupta R, McCarthy MI, Pearson ER, Bell JD, Pavo I, Franks PW. Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts. PLoS Med. 2020 Jun;17(6):e1003149. doi: 10.1371/journal.pmed.1003149. eCollection 2020 Jun. PubMed PMID: 32559194; PubMed Central PMCID: PMC7304567.
- S Taylor, K Smith, TE Capper, JH Scragg, A Bashir, A Flatt, EJ Stevenson, TJ McDonald, RA Oram, JA Shaw, DJ West. Post-exercise glycemic control in type 1 diabetes is associated with residual ꞵ-cell function. Diabetes Care 2020
- Leete P, Oram RA, McDonald TJ, Shields BM, Ziller C, Hattersley AT, Richardson SJ, Morgan NG. Studies of insulin and proinsulin in pancreas and serum support the existence of aetiopathological endotypes of type 1 diabetes associated with age at diagnosis. Diabetologia. 2020 Jun;63(6):1258-1267. doi: 10.1007/s00125-020-05115-6. Epub 2020 Mar 15. PubMed PMID: 32172310; PubMed Central PMCID: PMC7228905.
- Walker GJ, Chanchlani N, Thomas A, Lin S, Moore L, Heerasing NM, Hendy P, Abdelrahim M, Mole S, Perry MH, McDonald TJ, Bewshea CM, Hart JW, Russell RK, Ahmad T, Goodhand JR, Kennedy NA. Primary care faecal calprotectin testing in children with suspected inflammatory bowel disease: a diagnostic accuracy study. Arch Dis Child. 2020 May 18;. doi: 10.1136/archdischild-2019-317823. [Epub ahead of print] PubMed PMID: 32424002.
- Koivula RW, Atabaki-Pasdar N, Giordano GN, White T, Adamski J, Bell JD, Beulens J, Brage S, Brunak S, De Masi F, Dermitzakis ET, Forgie IM, Frost G, Hansen T, Hansen TH, Hattersley A, Kokkola T, Kurbasic A, Laakso M, Mari A, McDonald TJ, Pedersen O, Rutters F, Schwenk JM, Teare HJA, Thomas EL, Vinuela A, Mahajan A, McCarthy MI, Ruetten H, Walker M, Pearson E, Pavo I, Franks PW. The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study. Diabetologia. 2020 Apr;63(4):744-756. doi: 10.1007/s00125-019-05083-6. Epub 2020 Jan 30. PubMed PMID: 32002573; PubMed Central PMCID: PMC7054368.
- Jones AG, Shields BM, Dennis JM, Hattersley AT, McDonald TJ, Thomas NJ. The challenge of diagnosing type 1 diabetes in older adults. Diabet Med. 2020 Feb 11;. doi: 10.1111/dme.14272. [Epub ahead of print] PubMed PMID: 32043618.
- Peters JL, Anderson R, Shields B, King S, Hudson M, Shepherd M, McDonald TJ, Pearson E, Hattersley A, Hyde C. Strategies to identify individuals with monogenic diabetes: results of an economic evaluation. BMJ Open. 2020 Mar 18;10(3):e034716. doi: 10.1136/bmjopen-2019-034716. PubMed PMID: 32193268; PubMed Central PMCID: PMC7150598.
- Sazonovs A, Kennedy NA, Moutsianas L, Heap GA, Rice DL, Reppell M, Bewshea CM, Chanchlani N, Walker GJ, Perry MH, McDonald TJ, Lees CW, Cummings JRF, Parkes M, Mansfield JC, Barrett JC, McGovern D, Goodhand JR, Anderson CA, Ahmad T. HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn’s Disease. Gastroenterology. 2019 Oct 5;. doi: 10.1053/j.gastro.2019.09.041. PubMed PMID: 31600487.
- Bowman P, McDonald TJ, Knight BA, Flanagan SE, Leveridge M, Spaull SR, Shields BM, Hammersley S, Shepherd MH, Andrews RC, Patel KA, Hattersley AT. Patterns of postmeal insulin secretion in individuals with sulfonylurea-treated KCNJ11 neonatal diabetes show predominance of non-KATP-channel pathways. BMJ Open Diabetes Res Care. 2019;7(1):e000721. doi: 10.1136/bmjdrc-2019-000721. eCollection 2019. PubMed PMID: 31908791; PubMed Central PMCID: PMC6936449.
- Lynam A, McDonald TJ, Hill A, Dennis J, Oram R, Pearson E, Weedon M, Hattersley A, Owen K, Shields B, Jones A. Development and validation of multivariable clinical diagnostic models to identify type 1 diabetes requiring rapid insulin therapy in adults aged 18-50 years. BMJ Open. 2019 Sep 26;9(9):e031586. doi: 10.1136/bmjopen-2019-031586. PubMed PMID: 31558459; PubMed Central PMCID: PMC6773323.
- Flatt AJS, Little SA, Speight J, Leelarathna L, Walkinshaw E, Tan HK, Bowes A, Lubina-Solomon A, Holmes-Truscott E, Chadwick TJ, Wood R, McDonald TJ, Kerr D, Flanagan D, Brooks A, Heller SR, Evans ML, Shaw JAM. Predictors of Recurrent Severe Hypoglycemia in Adults With Type 1 Diabetes and Impaired Awareness of Hypoglycemia During the HypoCOMPaSS Study. Diabetes Care. 2019 Sep 4;. doi: 10.2337/dc19-0630. PubMed PMID: 31484666.
- Marren SM, Hammersley S, McDonald TJ, Shields BM, Knight BA, Hill A, Bolt R, Tree TI, Roep BO, Hattersley AT, Jones AG, Oram RA. Persistent C-peptide is associated with reduced hypoglycaemia but not HbA1c in adults with longstanding Type 1 diabetes: evidence for lack of intensive treatment in UK clinical practice?. Diabet Med. 2019 Sep;36(9):1092-1099. doi: 10.1111/dme.13960. Epub 2019 Jun 27. PubMed PMID: 30955221; PubMed Central PMCID: PMC6790586.
- Koivula RW, Forgie IM, Kurbasic A, Viñuela A, Heggie A, Giordano GN, Hansen TH, Hudson M, Koopman ADM, Rutters F, Siloaho M, Allin KH, Brage S, Brorsson CA, Dawed AY, De Masi F, Groves CJ, Kokkola T, Mahajan A, Perry MH, Rauh SP, Ridderstråle M, Teare HJA, Thomas EL, Tura A, Vestergaard H, White T, Adamski J, Bell JD, Beulens JW, Brunak S, Dermitzakis ET, Froguel P, Frost G, Gupta R, Hansen T, Hattersley A, Jablonka B, Kaye J, Laakso M, McDonald TJ, Pedersen O, Schwenk JM, Pavo I, Mari A, McCarthy MI, Ruetten H, Walker M, Pearson E, Franks PW. Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium. Diabetologia. 2019 Sep;62(9):1601-1615. doi: 10.1007/s00125-019-4906-1. Epub 2019 Jun 15. PubMed PMID: 31203377; PubMed Central PMCID: PMC6677872.
- Tura A, Grespan E, Göbl CS, Koivula RW, Franks PW, Pearson ER, Walker M, Forgie IM, Giordano GN, Pavo I, Ruetten H, Dermitzakis ET, McCarthy MI, Pedersen O, Schwenk JM, Adamski J, De Masi F, Tsirigos KD, Brunak S, Viñuela A, Mahajan A, McDonald TJ, Kokkola T, Vangipurapu J, Cederberg H, Laakso M, Rutters F, Elders PJM, Koopman ADM, Beulens JW, Ridderstråle M, Hansen TH, Allin KH, Hansen T, Vestergaard H, Mari A. Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study. Diabetes. 2021 Sep;70(9):2092-2106. doi: 10.2337/db21-0227. Epub 2021 Jul 7. PubMed PMID: 34233929.
- Lampasona V, Pittman DL, Williams AJ, Achenbach P, Schlosser M, Akolkar B, Winter WE. Islet Autoantibody Standardization Program 2018 Workshop: Interlaboratory Comparison of Glutamic Acid Decarboxylase Autoantibody Assay Performance. Clin Chem. 2019 Sep;65(9):1141-1152. doi: 10.1373/clinchem.2019.304196. Epub 2019 Aug 13. PubMed PMID: 31409598.
- Wilman HR, Parisinos CA, Atabaki-Pasdar N, Kelly M, Thomas EL, Neubauer S, Mahajan A, Hingorani AD, Patel RS, Hemingway H, Franks PW, Bell JD, Banerjee R, Yaghootkar H. Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration. J Hepatol. 2019 Sep;71(3):594-602. doi: 10.1016/j.jhep.2019.05.032. Epub 2019 Jun 19. PubMed PMID: 31226389; PubMed Central PMCID: PMC6694204.
- McKeigue PM, Spiliopoulou A, McGurnaghan S, Colombo M, Blackbourn L, McDonald TJ, Onengut-Gomuscu S, Rich SS, A Palmer CN, McKnight JA, J Strachan MW, Patrick AW, Chalmers J, Lindsay RS, Petrie JR, Thekkepat S, Collier A, MacRury S, Colhoun HM. Persistent C-peptide secretion in Type 1 diabetes and its relationship to the genetic architecture of diabetes. BMC Med. 2019 Aug 23;17(1):165. doi: 10.1186/s12916-019-1392-8. PubMed PMID: 31438962; PubMed Central PMCID: PMC6706940.
- Yaghootkar H, Abbasi F, Ghaemi N, Rabbani A, Wakeling MN, Eshraghi P, Enayati S, Vakili S, Heidari S, Patel K, Sayarifard F, Borhan-Dayani S, McDonald TJ, Ellard S, Hattersley AT, Amoli MM, Vakili R, Colclough K. Type 1 diabetes genetic risk score discriminates between monogenic and Type 1 diabetes in children diagnosed at the age of <5 years in the Iranian population. Diabet Med. 2019 Jul 5;. doi: 10.1111/dme.14071. [Epub ahead of print] PubMed PMID: 31276222.
- Thomas NJ, Lynam AL, Hill AV, Weedon MN, Shields BM, Oram RA, McDonald TJ, Hattersley AT, Jones AG. Type 1 diabetes defined by severe insulin deficiency occurs after 30 years of age and is commonly treated as type 2 diabetes. Diabetologia. 2019 Jul;62(7):1167-1172. doi: 10.1007/s00125-019-4863-8. Epub 2019 Apr 10. PubMed PMID: 30969375; PubMed Central PMCID: PMC6559997.
- Myngheer N, Allegaert K, Hattersley A, McDonald TJ, Kramer H, Ashcroft FM, Verhaeghe J, Mathieu C, Casteels K. Erratum. Fetal Macrosomia and Neonatal Hyperinsulinemic Hypoglycemia Associated With Transplacental Transfer of Sulfonylurea in a Mother With KCNJ11-Related Neonatal Diabetes. Diabetes Care 2014;37:3333-3335. Diabetes Care. 2019 Jul;42(7):1352. doi: 10.2337/dc19-er07. Epub 2019 May 21. PubMed PMID: 31221702.
- Koopman ADM, Beulens JW, Voerman E, Rauh SP, van der Heijden AA, McDonald TJ, Langendoen-Gort M, Rutters F. The association between GAD65 antibody levels and incident Type 2 Diabetes Mellitus in an adult population: A meta-analysis. Metabolism. 2019 Jun;95:1-7. doi: 10.1016/j.metabol.2019.03.001. Epub 2019 Mar 8. Review. PubMed PMID: 30853448.
- Kennedy NA, Heap GA, Green HD, Hamilton B, Bewshea C, Walker GJ, Thomas A, Nice R, Perry MH, Bouri S, Chanchlani N, Heerasing NM, Hendy P, Lin S, Gaya DR, Cummings JRF, Selinger CP, Lees CW, Hart AL, Parkes M, Sebastian S, Mansfield JC, Irving PM, Lindsay J, Russell RK, McDonald TJ, McGovern D, Goodhand JR, Ahmad T. Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn’s disease: a prospective, multicentre, cohort study. Lancet Gastroenterol Hepatol. 2019 May;4(5):341-353. doi: 10.1016/S2468-1253(19)30012-3. Epub 2019 Feb 27. PubMed PMID: 30824404.
- Chapman DP, Gooding KM, McDonald TJ, Shore AC. Stability of urinary albumin and creatinine after 12 months storage at -20 °C and -80 °C. Pract Lab Med. 2019 May;15:e00120. doi: 10.1016/j.plabm.2019.e00120. eCollection 2019 May. PubMed PMID: 30997374; PubMed Central PMCID: PMC6451166.
- Grubb AL, McDonald TJ, Rutters F, Donnelly LA, Hattersley AT, Oram RA, Palmer CNA, van der Heijden AA, Carr F, Elders PJM, Weedon MN, Slieker RC, ‘t Hart LM, Pearson ER, Shields BM, Jones AG. A Type 1 Diabetes Genetic Risk Score Can Identify Patients With GAD65 Autoantibody-Positive Type 2 Diabetes Who Rapidly Progress to Insulin Therapy. Diabetes Care. 2019 Feb;42(2):208-214. doi: 10.2337/dc18-0431. Epub 2018 Oct 23. PubMed PMID: 30352895.
- *Patel KA, Weedon MN, Shields BM, Pearson ER, Hattersley AT, McDonald TJ; UNITED study team.. Zinc Transporter 8 Autoantibodies (ZnT8A) and a Type 1 Diabetes Genetic Risk Score Can Exclude Individuals With Type 1 Diabetes From Inappropriate Genetic Testing for Monogenic Diabetes. Diabetes Care. 2018 Nov 8. pii: dc180373. doi: 10.2337/dc18-0373. [Epub ahead of print] PubMed PMID: 30409810.
- Teare HJA, de Masi F, Banasik K, Barnett A, Herrgard S, Jablonka B, Postma JWM, McDonald TJ, Forgie I, Chmura PJ, Rydzka EK, Gupta R, Brunak S, Pearson E, Kaye J. The governance structure for data access in the DIRECT consortium: an innovative medicines initiative (IMI) project. Life Sci Soc Policy. 2018 Sep 4;14(1):20. doi: 10.1186/s40504-018-0083-0. PubMed PMID: 30182269; PubMed Central PMCID: PMC6123336.
- Clissold RL, Fulford J, Hudson M, Shields BM, McDonald TJ, Ellard S, Hattersley AT, Bingham C. Exocrine pancreatic dysfunction is common in hepatocyte nuclear factor 1β-associated renal disease and can be symptomatic. Clin Kidney J. 2018 Aug;11(4):453-458. doi: 10.1093/ckj/sfx150. Epub 2018 Jan 30. PubMed PMID: 30094008; PubMed Central PMCID: PMC6070112.
- Shields BM, McDonald TJ, Oram R, Hill A, Hudson M, Leete P, Pearson ER, Richardson SJ, Morgan NG, Hattersley AT; TIGI Consortium.. C-Peptide Decline in Type 1 Diabetes Has Two Phases: An Initial Exponential Fall and a Subsequent Stable Phase.Diabetes Care. 2018 Jul;41(7):1486-1492. doi: 10.2337/dc18-0465. Epub 2018 Jun 7. PubMed PMID: 29880650; PubMed Central PMCID: PMC6027962.
- Jones AG, McDonald TJ. Comment on: Dulaglutide treatment results in effective glycaemic control in latent autoimmune diabetes in adults (LADA): A post-hoc analysis of the AWARD-2, -4 and -5 Trials. Diabetes Obes Metab. 2018 Mar 14. doi: 10.1111/dom.1329
- Knight AR, Taylor EL, Lukaszewski R, Jensen KT, Jones HE, Carré JE, Isupov MN, Littlechild JA, Bailey SJ, Brewer E, McDonald TJ, Pitt AR, Spickett CM, Winyard PG. A high-sensitivity electrochemiluminescence-based ELISA for the measurement of the oxidative stress biomarker, 3-nitrotyrosine, in human blood serum and cells. Free Radic Biol Med. 2018 Mar 17;120:246-254. doi: 10.1016/j.freeradbiomed.2018.03.026. PMID: 29555590
- Walker GJ, Moore L, Heerasing N, Hendy P, Perry MH, McDonald TJ, Debenham T, Bethune R, Bewshea C, Hyde C, Heap GA, Singh A, Calvert C, Kennedy NA, Goodhand JR, Ahmad T. Faecal calprotectin effectively excludes inflammatory bowel disease in 789 symptomatic young adults with/without alarm symptoms: a prospective UK primary care cohort study. Aliment Pharmacol Ther. 2018 Apr;47(8):1103-1116. doi: 10.1111/apt.14563. Epub 2018 Mar 5. PMID: 29508423
- Rhian L Clissold, Jon Fulford, Michelle Hudson, Beverley M Shields, Timothy J McDonald, Sian Ellard Andrew T Hattersley, Coralie Bingham. Exocrine pancreatic dysfunction is common in hepatocyte nuclear factor 1β–associated renal disease and can be symptomatic . Clinical Kidney Journal, Jan 2018
- Johnson MB, Patel KA, De Franco E, Houghton JAL, McDonald TJ, et al. A type 1 diabetes genetic risk score can discriminate monogenic autoimmunity with diabetes from early-onset clustering of polygenic autoimmunity with diabetes. Diabetologia. 2018 Feb 7;PubMed PMID: 29417186.
- Dennis JM, Shields BM, Hill AV, Knight BA, McDonald TJ, et al. Precision Medicine in Type 2 Diabetes: Clinical Markers of Insulin Resistance Are Associated With Altered Short- and Long-Term Glycemic Response to DPP-4 Inhibitor Therapy. Diabetes Care. 2018 Jan 31;PubMed PMID: 29386249.
- Hope SV, Knight BA, Shields BM, Hill AV, Choudhary P, Strain WD, McDonald TJ, Jones AG. Random non-fasting C-peptide testing can identify patients with insulin-treated type 2 diabetes at high risk of hypoglycaemia. Diabetologia. 2017 Oct PMID: 28983693.
- Shepherd, Colclough K, McDonald TJ. Tests aiding diagnosis of monogenic diabetes. Practical diabetes, Pract Diab, 2017 34: 217–220a. doi:10.1002/pdi.2122.
- McDonald TJ, Besser RE, Perry M, Babiker T, Knight BA, et al. Screening for neonatal diabetes at day 5 of life using dried blood spot glucose measurement. Diabetologia. 2017 Aug 5;PubMed PMID: 28779213.
- Shields BM, Shepherd M, Hudson M, McDonald TJ, Colclough K, et al. Population-Based Assessment of a Biomarker-Based Screening Pathway to Aid Diagnosis of Monogenic Diabetes in Young-Onset Patients. Diabetes Care. 2017 Aug;40(8):1017-1025. PubMed PMID: 28701371.
- Davidson J, McDonald TJ, Sutherland C, Mostazir M, VanAalten L, et al. Proinsulin is stable at room temperature for 24 hours in EDTA: A clinical laboratory analysis (adAPT 3). PLoS One. 2017;12(4):e0171716. PubMed PMID: 28426711; PubMed Central PMCID: PMC5398505.
- Chakera AJ, McDonald TJ, Knight BA, Vaidya B, Jones AG. Current laboratory requirements for adrenocorticotropic hormone and renin/aldosterone sample handling are unnecessarily restrictive. Clin Med (Lond). 2017 Feb;17(1):18-21. doi: 10.7861/clinmedicine.17-1-18. PMID: 28148573.
- Yubero D, Allen G, Artuch R, Montero R. The Value of Coenzyme Q(10) Determination in Mitochondrial Patients. J Clin Med. 2017;6(4):37.